BDBM21147 (3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-amino-3-formamidopropanoic acid]-3-[4-(sulfooxy)phenyl]propanamido]-4-(methylsulfanyl)butanamido]acetamido}-3-(1H-indol-3-yl)propanamido]-4-(methylsulfanyl)butanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid::CCK-8::CCK-8(SO3)::CHEMBL1121::H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2::SINCALIDE::Syncalide::[125I]CCK-8
SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
InChI Key InChIKey=IZTQOLKUZKXIRV-YRVFCXMDSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 52 hits for monomerid = 21147
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
TargetGastrin/cholecystokinin type B receptor(GUINEA PIG)
Fujisawa Pharmaceutical
Curated by PDSP Ki Database
Fujisawa Pharmaceutical
Curated by PDSP Ki Database
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataKi: 0.280nMAssay Description:Displacement of 0.2 nM [3H]-pCCK-8 from guinea pig brain membranesMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:Binding affinity against cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:Inhibitory activity of the compound against Cholecystokinin type B receptorMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
TargetGastrin/cholecystokinin type B receptor(GUINEA PIG)
Fujisawa Pharmaceutical
Curated by PDSP Ki Database
Fujisawa Pharmaceutical
Curated by PDSP Ki Database
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataKi: 0.410nMAssay Description:Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataKi: 0.410nMAssay Description:Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataKi: 0.600nMAssay Description:Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataKi: 0.600nMAssay Description:Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataKi: 0.640nMAssay Description:Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataKi: 0.640nMAssay Description:Tested for the inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataKi: 0.650nMAssay Description:The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(GUINEA PIG)
Fujisawa Pharmaceutical
Curated by PDSP Ki Database
Fujisawa Pharmaceutical
Curated by PDSP Ki Database
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataKi: 0.700nMAssay Description:Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataKi: 2.80nMAssay Description:Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(GUINEA PIG)
Fujisawa Pharmaceutical
Curated by PDSP Ki Database
Fujisawa Pharmaceutical
Curated by PDSP Ki Database
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataKd: 1.30nM EC50: 27nMAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Displacement of [125I]-Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataIC50: 0.316nMAssay Description:Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystok...More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataIC50: 0.316nMAssay Description:Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataIC50: 0.229nMAssay Description:Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Parke-Davis Neuroscience Research Centre
Curated by ChEMBL
Parke-Davis Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataEC50: 0.630nMAssay Description:Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataIC50: 0.120nMAssay Description:Displacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataIC50: 6nMAssay Description:Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Parke-Davis Neuroscience Research Centre
Curated by ChEMBL
Parke-Davis Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Parke-Davis Neuroscience Research Centre
Curated by ChEMBL
Parke-Davis Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Parke-Davis Neuroscience Research Centre
Curated by ChEMBL
Parke-Davis Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataIC50: 1nMAssay Description:Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataIC50: 8.20nMAssay Description:Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Parke-Davis Neuroscience Research Centre
Curated by ChEMBL
Parke-Davis Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Parke-Davis Neuroscience Research Centre
Curated by ChEMBL
Parke-Davis Neuroscience Research Centre
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataEC50: 0.630nMAssay Description:Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataIC50: 5.60nMAssay Description:Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataIC50: 5.60nMAssay Description:Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataIC50: 5.60nMAssay Description:Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(RAT)
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataIC50: 5.60nMAssay Description:Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataIC50: 0.320nMAssay Description:In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataIC50: 0.350nMAssay Description:Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataIC50: 0.320nMAssay Description:Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataIC50: 0.320nMAssay Description:Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transf...More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataEC50: 0.0930nMAssay Description:Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cellsMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris
Curated by ChEMBL
University Of Paris
Curated by ChEMBL
Affinity DataIC50: 0.120nMAssay Description:Displacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair